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Advantages of Closed-System Cell Processing

News & Insights

Closed-system cell processing is safer, more efficient, and more economical for the manipulation and processing of cells. Closed-system cell processing is when various equipment has been designed to minimize the risk of contamination and maintain cell viability by minimizing exposure to the environment and lab technicians. There are several advantages to using closed-system cell processing over traditional open-system cell processing methods.

Reduced Risk of Contamination

Closed-system cell processing greatly reduces the risk of contamination during cell manipulation and processing. The use of closed systems minimizes the potential for contamination from environmental sources, such as airborne particles and microorganisms. This helps to maintain the purity of the cell population and reduces the risk of adverse effects on patients.

Improved Quality Control

Closed-system cell processing provides greater control over the quality of the cell product and ensures a higher level of safety for both technicians and patients. The use of closed systems can allow for more precise and consistent handling of cells, which can result in a more uniform and reliable final product. Closed-system processing also provides greater control over critical process parameters, such as temperature and pH levels, which can impact cell viability and functionality.


Scalability is a crucial aspect of closed-system cell processing single-use disposables, enabling the seamless expansion of biotechnological processes to meet growing demands.  Closed-system cell processing is highly scalable and can be easily adapted to handle larger volumes of cells. Utilizing a closed system for transferring materials and items in larger volumes, offers enhanced convenience and reliability, particularly when producing larger batches of cell products.

Increased Efficiency

Closed-system cell processing is more efficient than traditional open-system methods. These disposable, closed systems offer streamlined and optimized workflows that eliminate the time-consuming steps of cleaning, sterilizing, and assembling traditional equipment. With improved efficiency, researchers and clinicians can achieve higher throughput, accelerate research and development, and deliver cell-based therapies to patients in a more timely and cost-effective manner.

Improved Safety

Closed-system cell processing is designed with safety in mind.  Many single-use disposable cell therapy products have Integrated safety features that minimize the risk of exposure and ensure the protection of researchers, technicians, and patients. Features such as barrier filters, aseptic connectors, and seals enhance the sterility and traceability of the entire process.


Closed-system cell processing not only protects the well-being of laboratory personnel but also significantly improves the quality and reliability of cell-based therapies, contributing to better patient outcomes and ultimately transforming the landscape of modern medicine. It offers several advantages over traditional open-system methods, like providing greater control over cell processing parameters, reducing the risk of contamination, being highly scalable, increasing efficiency, and improving overall safety. These benefits make closed-system cell processing an attractive option for the production of cell-based therapeutics, and its use is likely to increase as cell-based therapies continue to advance.

Using Cell Culture Bags in Closed-System Cell Processing

Cell culture bags play a pivotal role in closed-system cell processing, offering numerous advantages and facilitating the seamless execution of various biotechnological applications. OriGen is proud to offer two different cell culture bags to fit our customer’s various needs: PermaLife™ Cell Culture Bag and Evolve Cell Culture Bag. The use of cell culture bags in closed-system cell processing ensures the sterility and integrity of the cell culture throughout the entire process. One of the key benefits of using cell culture bags in closed-system cell processing is their ability to support large-scale cell culture. These bags can accommodate large volumes of cells, making them well-suited for the production of cell-based therapeutics in high quantities.

In addition, cell culture bags are often designed with features that enable efficient and controlled cell processing. Cell culture bags are made with materials that maintain optimal conditions for cell growth and proliferation while providing excellent gas exchange. The transparency of the bags allows for easy monitoring of cell growth and viability without the need for sample removal, reducing the risk of contamination and disturbances. 


Cell culture bags are also easy to handle and transport, and can be stored until they are ready for use. This can help to simplify the logistics of cell processing, making it easier to move cells from one location to another as needed. While they are designed to be durable and leak-resistant, they may still be susceptible to damage from handling or other environmental factors. This can be mitigated through careful handling and inspection of bags prior to use.


Cell culture bags are an important component of closed-system cell processing. The use of cell culture bags in a closed-system approach enhances the safety, reproducibility, and efficiency of cell processing, facilitating better control over culture conditions and improving overall productivity in biotechnological applications.